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reported that the decrease of NAD+/NADH ratio will cause a decrease in silent mating-type information regulation 2 homolog 3 (SIRT3) activity, while the decrease of SIRT3 activity can increase the acetylation level of CypD, which can induce the open and membrane potential depolarization of mPTP by inducing the acetylation of CypD (Yang et al., 2015)

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Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway